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Image Search Results
Journal: Frontiers in Molecular Neuroscience
Article Title: Type 2 cytokines sensitize human sensory neurons to itch-associated stimuli
doi: 10.3389/fnmol.2023.1258823
Figure Lengend Snippet: (A) t-SNE with Louvain clustering of DRG neurons from reanalyzed single nuclei RNA sequencing . (B) Expression density of select genes on the t-SNE plot. (C) Average expression level and frequency of selected marker genes of established neuronal subsets within each cluster. (D) Average expression level and frequency of genes selected during marker. Analysis of putative pruriceptors clusters C6, C9, and C11 from BioTuring “ find markers ” function. (E) Average expression level and frequency of select genes involved in type 2 cytokine receptor signaling within each cluster. (F) t-SNE plots depicting the expression density of type 2 cytokine receptors IL-4Rα and IL-13Rα1. (G) Enrichment scores of type 2 cytokine-associated signaling genes highlighted in blue in panel (E) . AUCell score for each neuron is represented in the indicated color scale for each cell in the scatter plot (top) and as an average for each cluster (bottom). DRG, dorsal root ganglion; IL, interleukin; t-SNE, t-distributed stochastic neighbor embedding.
Article Snippet: Raw data from were reanalyzed and visualized with 2D t-distributed stochastic neighbor embedding (t-SNE) with
Techniques: RNA Sequencing, Expressing, Marker
Journal: Frontiers in Molecular Neuroscience
Article Title: Type 2 cytokines sensitize human sensory neurons to itch-associated stimuli
doi: 10.3389/fnmol.2023.1258823
Figure Lengend Snippet: (A) t-SNE with Louvain clustering of DRG neurons from reanalyzed single nuclei RNA sequencing . (B) Expression density of select genes on the t-SNE plot. (C) Average expression level and frequency of selected marker genes of established neuronal subsets within each cluster. (D) Average expression level and frequency of genes selected during marker. Analysis of putative pruriceptors clusters C6, C9, and C11 from BioTuring “ find markers ” function. (E) Average expression level and frequency of select genes involved in type 2 cytokine receptor signaling within each cluster. (F) t-SNE plots depicting the expression density of type 2 cytokine receptors IL-4Rα and IL-13Rα1. (G) Enrichment scores of type 2 cytokine-associated signaling genes highlighted in blue in panel (E) . AUCell score for each neuron is represented in the indicated color scale for each cell in the scatter plot (top) and as an average for each cluster (bottom). DRG, dorsal root ganglion; IL, interleukin; t-SNE, t-distributed stochastic neighbor embedding.
Article Snippet: Therefore, we performed an additional analysis looking at the composite enrichment of receptors and signaling components associated with IL-4, IL-13, and IL-33 using the
Techniques: RNA Sequencing, Expressing, Marker